A new method for prediction of droplet size distributions from subsea oil and gas releases is presented in this paper. The method is based on experimental data obtained from oil droplet breakup experiments conducted in a new test facility at SINTEF. The facility is described in a companion paper, while this paper deals with the theoretical basis for the model and the empirical correlations used to derive the model parameters from the available data from the test facility. A major issue dealt with in this paper is the basis for extrapolation of the data to full scale (blowout) conditions. Possible contribution from factors such as buoyancy flux and gas void fraction are discussed and evaluated based on results from the DeepSpill field experiment.